Baldness and Risk of Prostate Cancer in the Health Professionals Follow-up Study.

ABSTRACT:

Background

The association between male pattern baldness and prostate cancer has been inconsistent. We prospectively investigated the association between baldness at age 45 and prostate cancer risk in the Health Professionals Follow-up Study (HPFS), focusing on clinical and molecular markers.

Methods

Baldness was self-reported on the 1992 questionnaire using the modified Norwood-Hamilton scale prior to diagnosis. We estimated HRs between baldness and prostate cancer risk among 36,760 men, with follow-up through 2014. We also investigated whether baldness was associated with prostate cancer defined by tumor protein expression of androgen receptor and the presence of the TMPRSS2:ERG fusion.

Results

During 22 years, 5,157 prostate cancer cases were identified. Fifty-six

SUBMITTER: Khan S 

PROVIDER: S-EPMC7269836 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature