Risk factors differ by first manifestation of cardiovascular disease in type 1 diabetes.

ABSTRACT:

Aims

We compared risk factors for three CVD manifestations and a composite outcome over 25 years' follow-up in the Pittsburgh Epidemiology of Diabetes Complications (EDC) prospective cohort study of childhood-onset (<17 years) type 1 diabetes (n = 658).

Methods

First CVD manifestations examined were: (1) major atherosclerotic cardiovascular event (MACE, i.e. CVD death, myocardial infarction, stroke), (2) coronary revascularization, (3) soft coronary artery disease (CAD, i.e. ischemia ECG, angina), and a (4) composite (MACE + revascularization) outcome. Baseline and time-varying mean and current risk factors, including medication use, were assessed, in diabetes duration-adjusted models.

Results

MACE (n = 107) was predicted by ln(albumin excretion rate) (AER, HR = 1.3,

SUBMITTER: Miller RG 

PROVIDER: S-EPMC7269839 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature