Probiotics ameliorate intestinal pathophysiology in a mouse model of Alzheimer's disease.

ABSTRACT: Evidence suggests that changes in intestinal microbiota may affect the central nervous system. However, it is unclear whether alteration of intestinal microbiota affects progression of Alzheimer's disease (AD). To understand this, wild-type control (C57BL/6) mice were compared with the App^NL-G-F model of disease. We used probiotic supplementation to manipulate the gut microbiota. Fecal samples were collected for microbiota profiling. To study brain and intestinal inflammation, biochemical and histological analyses were performed. Altered metabolic pathways were examined by quantifying eicosanoid and bile acid profiles in the brain and serum using ultraperformance liquid chromatography-tandem mass spectrometry. We observed that brain pathology was associated with intestinal dysbi

SUBMITTER: Kaur H 

PROVIDER: S-EPMC7269849 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature