Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.

ABSTRACT:

Purpose

Unlike most cancers, no clear epidemiological correlation between diabetes (Db) and malignant glioma progression exists. Because hyperglycemia activates proinflammatory pathways through the receptor for advanced glycation endproducts (RAGE), we hypothesized that Db can also promote malignant glioma progression.

Experimental design

We compared the growth of two phenotypically diverse syngeneic glioma models in control and diabetic mice. Tumor growth and antitumor immune responses were evaluated in orthotopic and heterotopic models and correlated to RAGE and RAGE ligand expression.

Results

Irrespective of tumor implantation site, growth of a "classical" glioma model, GL261, increased in hyperglycemic mice and was mediated by upregulation of RAGE and its ligand,

SUBMITTER: Zhang IY 

PROVIDER: S-EPMC7269856 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature