Response to fluoxetine in children and adolescents: a weighted gene co-expression network analysis of peripheral blood.

ABSTRACT: The inconclusive and non-replicated results of pharmacogenetic studies of antidepressant response could be related to the lack of acknowledgement of its mechanism of action. In this scenario, gene expression studies provide and interesting framework to reveal new candidate genes for pharmacogenetic studies or peripheral biomarkers of fluoxetine response. We propose a system biology approach to analyse changes in gene expression induced by eight weeks of treatment with fluoxetine in peripheral blood. 21 naïve child and adolescents participated in the present study. Our analysis include the identification of gene co-expression modules, using Weighted Gene Co-expression Network Analysis (WGCNA), followed by protein-protein interaction (PPi) network construction coupled with functional annotat

SUBMITTER: Torres T 

PROVIDER: S-EPMC7269974 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature