Mortality after transcatheter versus surgical aortic valve replacement: an updated meta-analysis of randomised trials.

ABSTRACT:

Background

To determine whether transcatheter aortic valve implantation (TAVI) improves early (30-day) and midterm (1-year) mortality compared with surgical aortic valve replacement (SAVR), we performed an updated meta-analysis of all the currently available randomised controlled trials (RCTs).

Methods

To identify all RCTs providing both 30-day and 1‑year mortality after TAVI versus SAVR, PubMed and ClinicalTrials.gov were searched up to and including July 2019. A risk difference (RD) and its 95% confidence interval were generated using data of prespecified outcomes in both the TAVI and SAVR groups. Study-specific estimates were pooled using inverse variance-weighted averages of RDs in the random-effects model.

Results

We identified seven eligible high-quality RCTs in

SUBMITTER: Takagi H 

PROVIDER: S-EPMC7270388 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature