Genome sequencing and analysis of fungus Hirsutella sinensis isolated from Ophiocordyceps sinensis.

ABSTRACT: Ophiocordyceps sinensis has been used as a traditional medicine or healthy food in China for thousands of years. Hirsutella sinensis was reported as the only correct anamorph of O. sinensis. It is reported that the laboratory-grown H. sinensis mycelium has similar clinical efficacy and less associated toxicity compared to the wild O. sinensis. The research of the H. sinensis is becoming more and more important and urgent. To gain deeper insight into the biological and pharmacological mechanisms, we sequenced the genome of H. sinensis. The genome of H. sinensis (102.72 Mb) was obtained for the first time, with > 99% coverage. 10,200 protein-encoding genes were predicted based on the genome sequence. A detailed secondary metabolism analysis and structure verification of the main ingredients

SUBMITTER: Jin LQ 

PROVIDER: S-EPMC7270455 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature