In vivo histopathological staging in C9orf72-associated ALS: A tract of interest DTI study.

ABSTRACT:

Background

Diffusion tensor imaging (DTI) can identify amyotrophic lateral sclerosis (ALS)-associated patterns of brain alterations at the group level according to a neuropathological staging system.

Objective

The study was designed to investigate the in vivo staging in ALS patients with the C9orf72 expansion and potential differences to ALS patients with the SOD1 mutation.

Methods

DTI-based white matter mapping was performed both by an unbiased voxel-wise statistical comparison and by a hypothesis-guided tract-wise analysis of fractional anisotropy (FA) maps according to the ALS-staging pattern for 27 ALS patients with C9orf72 expansion vs 15 ALS patients with SOD1 mutation vs 32 matched healthy controls. Clinical and neuropsychological data were acquired and correla

SUBMITTER: Muller HP 

PROVIDER: S-EPMC7270604 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature