Does combination therapy work in chronic thromboembolic pulmonary hypertension?

ABSTRACT:

Objective

The current experience with combination therapy in chronic thromboembolic pulmonary hypertension (CTEPH) is limited. We present the first survival results up to 5 years for dual combination therapy versus monotherapy in CTEPH.

Methods

All consecutive, non-operated CTEPH or residual PH after pulmonary endarterectomy patients treated with PH-specific medical therapy between January 2002 and November 2019 were included. We report and compare survival between monotherapy and (upfront or sequential) dual combination therapy until five years after medication initiation.

Results

In total, 183 patients (mean age 65 ± 14 years, 60% female, 66% WHO FC III/IV, 86% non-operated) were included, of which 83 patients received monotherapy and 100 patients received dual comb

SUBMITTER: van Thor MCJ 

PROVIDER: S-EPMC7270605 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature