A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.

ABSTRACT:

Purpose

COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.

Methods

PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19.

Results

We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causi

SUBMITTER: Cortegiani A 

PROVIDER: S-EPMC7270792 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature