Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial.

ABSTRACT:

Importance

Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed.

Objective

To evaluate the efficacy and adverse effects of convalescent plasma therapy for patients with COVID-19.

Design, setting, and participants

Open-label, multicenter, randomized clinical trial performed in 7 medical centers in Wuhan, China, from February 14, 2020, to April 1, 2020, with final follow-up April 28, 2020. The trial included 103 participants with laboratory-confirmed COVID-19 that was severe (respiratory distress and/or hypoxemia) or life-threatening (shock, organ failure, or requiring mechanical ventilation). The trial was terminated early after 103 of a planned 200 patie

SUBMITTER: Li L 

PROVIDER: S-EPMC7270883 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature