Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.

ABSTRACT:

Importance

With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD).

Objectives

To detect genetic risk variants for OUD and determine genetic correlations and causal association with OUD and other traits.

Design, setting, and participants

A genome-wide association study of electronic health record-defined OUD in the Million Veteran Program sample was conducted, comprising 8529 affected European American individuals and 71 200 opioid-exposed European American controls (defined by electronic health record trajectory analysis) and 4032 affected African American individuals and 26 029 opioid-exposed African American controls. Participants were enrolled from January 10, 2011, to May 21, 2018, with el

SUBMITTER: Zhou H 

PROVIDER: S-EPMC7270886 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature