Multi-sulfonated ligands on gold nanoparticles as virucidal antiviral for Dengue virus.

ABSTRACT: Dengue virus (DENV) causes 390 million infections per year. Infections can be asymptomatic or range from mild fever to severe haemorrhagic fever and shock syndrome. Currently, no effective antivirals or safe universal vaccine is available. In the present work we tested different gold nanoparticles (AuNP) coated with ligands ω-terminated with sugars bearing multiple sulfonate groups. We aimed to identify compounds with antiviral properties due to irreversible (virucidal) rather than reversible (virustatic) inhibition. The ligands varied in length, in number of sulfonated groups as well as their spatial orientation induced by the sugar head groups. We identified two candidates, a glucose- and a lactose-based ligand showing a low EC₅₀ (effective concentration that inhibit 50% of th

SUBMITTER: Zacheo A 

PROVIDER: S-EPMC7271158 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature