Molecular Interaction between Distal C-Terminal Domain of the CB₁ Cannabinoid Receptor and Cannabinoid Receptor Interacting Proteins (CRIP1a/CRIP1b).

ABSTRACT: We have investigated the structure of the distal C-terminal domain of the of the CB₁ cannabinoid receptor (CB1R) to study its interactions with CRIP1a and CRIP1b using computational techniques. The amino acid sequence from the distal C-terminal domain of CB1R (G⁴¹⁷-L⁴⁷²) was found to be unique, as it does not share sequence similarity with other protein structures, so the structure was predicted using ab initio modeling. The computed model of the distal C-terminal region of CB1R has a helical region between positions 441 and 455. The CRIP1a and CRIP1b were modeled using Rho-GDI 2 as a template. The three-dimensional model of the distal C-terminal domain of the CB1R was docked with both CRIP1a as well as CRIP1b to study the crucial interactions betwee

SUBMITTER: Singh P 

PROVIDER: S-EPMC7271255 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature