Systems Studies Uncover miR-146a as a Target in Leishmania major Infection Model.

ABSTRACT: Leishmaniasis, the second most neglected tropical disease, has been reported to affect approximately 12 million people worldwide. The causative protozoan parasite Leishmania has shown drug resistance to available chemotherapies, owing to which we need to look for better approaches to deal with the clinical situations. As per recent reports, several miRNAs have been found to be differentially expressed during Leishmania major infection in host macrophages. We aim to evaluate the impact of miRNA-mediated gene regulation on the key players of inflammation and macrophage dysfunction. The origin of Leishmania miRNAs and their processing is a questionable phenomenon as of yet. Through our study, we aim to provide a framework of their characterization. We amalgamate chemical

SUBMITTER: Nimsarkar P 

PROVIDER: S-EPMC7271362 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature