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Anti-inflammatory Withanolides from Physalis minima.


ABSTRACT: Five new withanolides (1-5) along with five known ones (6-10) were isolated from the whole plants of Physalis minima Linn. The chemical structures of the new compounds were identified as (20S,22R) 15a-acetoxy-5?,6?-epoxy-4?,14a,28-trihydroxy-3?-methoxy-1-oxowitha-16,24-dienolide (1), (20S,22R) 15a-acetoxy-5?,6?-epoxy-3?,4?,14?,17?,20?-pentahydroxy-1-oxowitha-24-enolide (2), (20R,22R) 15?-acetoxy-4?,5?,6?,14?,20?-pentahydroxy-1-oxowitha-2,24-dienolide (3), (20R,22R) 15?-acetoxy-5?,6?,14?,20?-tetrahydroxy-1-oxowitha-2,24-dienolide (4), and (20S,22R) 5?,6?,14?-trihydroxy-1,15-dioxowitha-2,16,24-trienolide (5) on the basis of integration combining IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR analyses. Biologically, compounds (1-10) were subjected to evaluate their anti-inflammatory activities via inhibiting nitric oxide production in lipopolysaccharide-stimulated murine RAW 264.7 cells in vitro. The activity screening indicated that all of the compounds showed a moderate inhibitory effect against nitric oxide production with IC50 values of 23.53-66.28 ?M.

SUBMITTER: Wu J 

PROVIDER: S-EPMC7271383 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Anti-inflammatory Withanolides from <i>Physalis minima</i>.

Wu Jiangping J   Zhang Tao T   Yu Meng M   Jia Hongmei H   Zhang Hongwu H   Xu Qiongming Q   Gu Yucheng Y   Zou Zhongmei Z  

ACS omega 20200517 21


Five new withanolides (<b>1-5</b>) along with five known ones (<b>6-10</b>) were isolated from the whole plants of <i>Physalis minima</i> Linn. The chemical structures of the new compounds were identified as (20<i>S</i>,22<i>R</i>) 15<i>a</i>-acetoxy-5β,6β-epoxy-4β,14<i>a</i>,28-trihydroxy-3β-methoxy-1-oxowitha-16,24-dienolide (<b>1</b>), (20<i>S</i>,22<i>R</i>) 15<i>a</i>-acetoxy-5β,6β-epoxy-3β,4β,14β,17β,20β-pentahydroxy-1-oxowitha-24-enolide (<b>2</b>), (20<i>R</i>,22<i>R</i>) 15α-acetoxy-4β,  ...[more]

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