Yolk sac tumor differentiation in urothelial carcinoma of the urinary bladder: a case report and differential diagnosis.

ABSTRACT:

Background

Yolk sac tumor (YST) is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These latter cases have been documented in several organs, although reports from the urinary tract are limited. To our knowledge, this is the first report of a bladder urothelial carcinoma with a predominant component of YST differentiation.

Case presentation

We present a unique case of a 76-year-old man with a recurrent urinary bladder tumor, initially interpreted as a high grade urothelial carcinoma with glandular differentiation. In the recurrent tumor, diverse histological patterns were identified, including glandular, hepatoid and sarcomatoid. This tumor showed positivity for AFP, GLP3 and SALL4, and negat

SUBMITTER: Espejo-Herrera N 

PROVIDER: S-EPMC7271425 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature