Elastic power but not driving power is the key promoter of ventilator-induced lung injury in experimental acute respiratory distress syndrome.

ABSTRACT:

Background

We dissected total power into its primary components to resolve its relative contributions to tissue damage (VILI). We hypothesized that driving power or elastic (dynamic) power offers more precise VILI risk indicators than raw total power. The relative correlations of these three measures of power with VILI-induced histologic changes and injury biomarkers were determined using a rodent model of acute respiratory distress syndrome (ARDS). Herein, we have significantly extended the scope of our previous research.

Methods

Data analyses were performed in male Wistar rats that received endotoxin intratracheally to induce ARDS. After 24 h, they were randomized to 1 h of volume-controlled ventilation with low V_T = 6 ml/kg and different PEEP levels (3, 5.5, 7.

SUBMITTER: Rocco PRM 

PROVIDER: S-EPMC7271482 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature