Thermogenic diagnosis of periprosthetic joint infection by microcalorimetry of synovial fluid.

ABSTRACT:

Background

Synovial fluid culture is the standard investigation for the preoperative diagnosis of periprosthetic joint infection (PJI). However, the culture has limited sensitivity and requires several days until result. We evaluated the value of isothermal microcalorimetry for real-time diagnosis of PJI based on heat produced by microbial growth in synovial fluid.

Methods

Patients undergoing aspiration of prosthetic hip or knee joint before revision surgery were prospectively included between 2014 and 2015. The performance of microcalorimetry was compared to synovial fluid culture using McNemar's chi-squared test. Pearson's correlation coefficient was calculated for synovial fluid leukocyte count and microcalorimetric heat.

Results

Of 107 included patients (58 knee a

SUBMITTER: Morgenstern C 

PROVIDER: S-EPMC7271508 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature