Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial.

ABSTRACT:

Importance

Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There currently appears to be no evidence-based pharmacotherapies for the primary prevention of depression.

Objective

To determine whether low-dose aspirin (100 mg) reduces the risk of depression in healthy older adults.

Design, setting, and participants

This double-blinded, placebo-controlled randomized clinical trial was a substudy of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, which examined if aspirin increased healthy life span, defined as

SUBMITTER: Berk M 

PROVIDER: S-EPMC7271558 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature