A laboratory-based scoring system predicts early treatment in Rai 0 chronic lymphocytic leukemia.

ABSTRACT: We present a laboratory-based prognostic calculator (designated CRO score) to risk stratify treatment-free survival in early stage (Rai 0) chronic lymphocytic leukemia (CLL) developed using a training-validation model in a series of 1,879 cases from Italy, the United Kingdom and the United States. By means of regression analysis, we identified five prognostic variables with weighting as follows: deletion of the short arm of chromosome 17 and unmutated immunoglobulin heavy chain gene status, 2 points; deletion of the long arm of chromosome 11, trisomy of chromosome 12, and white blood cell count >32.0x10³/microliter, 1 point. Low-, intermediate- and high-risk categories were established by recursive partitioning in a training cohort of 478 cases, and then validated in four indepe

SUBMITTER: Cohen JA 

PROVIDER: S-EPMC7271568 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature