The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T cells.

ABSTRACT: CD4⁺ T-follicular helper cells are essential for the survival, proliferation, and differentiation of germinal center B cells and have been implicated in the pathogenesis of follicular lymphoma (FL). To further define the role of these cells in FL, we used multiparameter confocal microscopy to compare the architecture of normal and neoplastic follicles and next generation sequencing to analyze the T-cell receptor repertoire in FL lymph nodes (LN). Multiparameter analysis of LN showed that the proportion of T-follic-ular helper cells (T_FH) in normal and neoplastic follicles is the same and that the previously reported increase in T_FH numbers in FL is thus due to an increase in the number and not content of follicles. As in normal germinal centers, T_FH

SUBMITTER: Townsend W 

PROVIDER: S-EPMC7271595 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature