Effect of Alteplase Administration on International Normalized Ratio in Patients With Acute Ischemic Stroke.

ABSTRACT:

Background/objective

Alteplase may elevate international normalized ratio (INR) results, although the exact rate of elevation occurrence is not firmly established in the literature. The purpose of this study is to determine the occurrence rate of INR elevation following alteplase administration. We also aimed to determine what factors are independently associated with the development of elevated INR following alteplase administration for ischemic stroke.

Methods

We conducted a multicenter, retrospective, cohort study of patients who received alteplase for acute ischemic stroke. Patients were screened for baseline INR measurement and a repeat value within 24 hours of alteplase administration. The primary outcome was the percent of patients who experienced ≥0.4-point increase

SUBMITTER: Erdman MJ 

PROVIDER: S-EPMC7271619 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature