Efficacy of Surface-Modified PLGA Nanoparticles as a Function of Cervical Cancer Type.

ABSTRACT:

Purpose

Hypovascularization of cervical tumors, coupled with intrinsic and acquired drug resistance, has contributed to marginal therapeutic outcomes by hindering chemotherapeutic transport and efficacy. Recently, the heterogeneous penetration and distribution of cell penetrating peptide (CPP, here MPG) and polyethylene glycol (PEG) modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were evaluated as a function of tumor type and morphology in cervical cancer spheroids modeling hypovascularized tumor nodules. Building upon this work, this study investigates the efficacy imparted by surface-modified Doxorubicin-loaded NPs transported into hypovascularized tissue.

Methods

NP efficacy was measured in HeLa, CaSki, and SiHa cells. NP internalization and association,

SUBMITTER: Sims LB 

PROVIDER: S-EPMC7271733 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature