Whole-vessel coronary ¹⁸F-sodium fluoride PET for assessment of the global coronary microcalcification burden.

ABSTRACT:

Purpose

¹⁸F-sodium fluoride (¹⁸F-NaF) has shown promise in assessing disease activity in coronary arteries, but currently used measures of activity - such as maximum target to background ratio (TBRmax) - are defined by single pixel count values. We aimed to develop a novel coronary-specific measure of ¹⁸F-NaF PET reflecting activity throughout the entire coronary vasculature (coronary microcalcification activity [CMA]).

Methods

Patients with recent myocardial infarction and multi-vessel coronary artery disease underwent ¹⁸F-NaF PET and coronary CT angiography. We assessed the association between coronary ¹⁸F-NaF uptake (both TBRmax and CMA) and coronary artery calcium scores (CACS) as well as low attenuation plaque (LAP,

SUBMITTER: Kwiecinski J 

PROVIDER: S-EPMC7271818 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature