Pressure-Sensitive Tissue Adhesion and Biodegradation of Viscoelastic Polymer Blends.

ABSTRACT: Viscoelastic blends of biodegradable polyesters with low and high molecular weight distributions have remarkably strong adhesion (significantly greater than 1 N/cm²) to soft, wet tissue. Those that transition from viscous flow to elastic, solidlike behavior at approximately 1 Hz demonstrate pressure-sensitivity yet also have sufficient elasticity for durable bonding to soft, wet tissue. The pressure-sensitive tissue adhesive (PSTA) blends produce increasingly stronger pull-apart adhesion in response to compressive pressure application, from 10 to 300 s. By incorporating a stiffer high molecular weight component, the PSTA exhibits dramatically improved burst pressure (greater than 100 kPa) when used as a tissue sealant. The PSTA's biodegradation mechanism can be switched from ero

SUBMITTER: Daristotle JL 

PROVIDER: S-EPMC7271901 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature