Peripheral blood transcriptome identifies high-risk benign and malignant breast lesions.

ABSTRACT: BACKGROUND:Peripheral blood transcriptome profiling is a potentially important tool for disease detection. We utilize this technique in a case-control study to identify candidate transcriptomic biomarkers able to differentiate women with breast lesions from normal controls. METHODS:Whole blood samples were collected from 50 women with high-risk breast lesions, 57 with breast cancers and 44 controls (151 samples). Blood gene expression profiling was carried out using microarray hybridization. We identified blood gene expression signatures using AdaBoost, and constructed a predictive model differentiating breast lesions from controls. Model performance was then characterized by AUC sensitivity, specificity and accuracy. Biomarker biological processes and functions were analyzed for clues to

SUBMITTER: Hou H 

PROVIDER: S-EPMC7272048 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature