Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes.

ABSTRACT: Eukaryotic flagella are complex microtubule-based organelles that, in many organisms, contain extra-axonemal structures, such as the outer dense fibres of mammalian sperm and the paraflagellar rod (PFR) of trypanosomes. Flagellum assembly is a complex process occurring across three main compartments, the cytoplasm, the transition zone and the flagellum itself. The process begins with the translation of protein components followed by their sorting and trafficking into the flagellum, transport to the assembly site and incorporation. Flagella are formed from over 500 proteins and the principles governing assembly of the axonemal components are relatively clear. However, the coordination and location of assembly of extra-axonemal structures are less clear. We have discovered two cytoplasmic pr

SUBMITTER: Alves AA 

PROVIDER: S-EPMC7272336 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature