Tiered approach for the identification of Mal d 1 reduced, well tolerated apple genotypes.

ABSTRACT: A rising proportion of the world population suffers from food-related allergies, including incompatibilities to apples. Although several allergenic proteins have been found in apples, the most important proteins that cause allergic reactions to apples in Central-Northern Europe, and North America are the Mal d 1 proteins, which are homologues of the birch pollen allergen Bet v 1. As the demand for hypoallergenic fruits is constantly increasing, we selected apple genotypes with a low total content of Mal d 1 by enzyme-linked immunosorbent assay analysis from segregating populations and tested the tolerability of these fruits through a human provocation study. This tiered approach, which exploited the natural diversity of apples, led to the identification of fruits, which were tolerated by a

SUBMITTER: Romer E 

PROVIDER: S-EPMC7272412 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature