Reconsolidation-based treatment for fear of public speaking: a systematic pilot study using propranolol.

ABSTRACT: Pharmacological manipulation of memory reconsolidation opens up promising new avenues for anxiety disorder treatment. However, few studies have directly investigated reconsolidation-based approaches in subclinical or clinical populations, leaving optimal means of fear memory reactivation unknown. We conducted a systematic pilot study to assess whether a reconsolidation-based treatment could tackle public speaking anxiety in a subclinical sample (N = 60). As lab studies indicate that the duration of reactivation may be important for inducing reconsolidation, we investigated several speech lengths to help inform further translational efforts. Participants underwent a stress-inducing speech task composed of 3-min preparation, and from 0 to 9 min of public speaking, in 1-min increments. They t

SUBMITTER: Elsey JWB 

PROVIDER: S-EPMC7272450 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature