Common Gene Modules Identified for Chicken Adiposity by Network Construction and Comparison.

ABSTRACT: Excessive fat deposition can cause chicken health problem, and affect production efficiency by causing great economic losses to the industry. However, the molecular underpinnings of the complex adiposity trait remain elusive. In the current study, we constructed and compared the gene co-expression networks on four transcriptome profiling datasets, from two chicken lines under divergent selection for abdominal fat contents, in an attempt to dissect network compositions underlying adipose tissue growth and development. After functional enrichment analysis, nine network modules important to adipogenesis were discovered to be involved in lipid metabolism, PPAR and insulin signaling pathways, and contained hub genes related to adipogenesis, cell cycle, inflammation, and protein synthesis. Moreo

SUBMITTER: Gao Z 

PROVIDER: S-EPMC7272656 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature