Project description:Introduction: The ongoing pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed important challenges for clinicians and health-care systems worldwide.Areas covered: The aim of this manuscript is to provide brief guidance for intensive care unit management of mechanically ventilated patients with COVID-19 based on the literature and our direct experience with this population. PubMed, EBSCO, and the Cochrane Library were searched up until 15th of January 2021 for relevant literature.Expert opinion: Initially, the respiratory management of COVID-19 relied on the general therapeutic principles for acute respiratory distress syndrome; however, recent findings have suggested that the pathophysiology of hypoxemia in patients with COVID-19 presents specific features and changes over time. Several therapies, including antiviral and anti-inflammatory agents, have been proposed recently. The optimal intensive care unit management of patients with COVID-19 remains unclear; therefore, ongoing and future clinical trials are warranted to clarify the optimal strategies to adopt in this cohort of patients.
Project description:Macromolecular refinement is an optimization process that aims to produce the most likely macromolecular structural model in the light of experimental data. As such, macromolecular refinement is one of the most complex optimization problems in wide use. Macromolecular refinement programs have to deal with the complex relationship between the parameters of the atomic model and the experimental data, as well as a large number of types of prior knowledge about chemical structure. This paper draws attention to areas of unfinished business in the field of macromolecular refinement. In it, we describe ten refinement topics that we think deserve attention and discuss directions leading to macromolecular refinement software that would make the best use of modern computer resources to meet the needs of structural biologists of the twenty-first century.
Project description:The cornovirus disease (COVID-19) pandemic has had a severe impact on our daily lives. As a result, there has been an increasing demand for technological solutions to overcome such challenges. The Internet of Things (IoT) has recently emerged to improve many aspects of human's day-to-day activities and routines. IoT makes it easier to follow the safety guidelines and precautions provided by the World Health Organization (WHO). Prior reports have shown that the world nowadays may need more IoT facilities than ever before. However, little is known about the reaction of the IoT community towards defeating the COVID-19 pandemic, technologies being used, solutions being provided, and how our societies perceive the IoT means available to them. In this paper, we conduct an empirical study to investigate the IoT response to the COVID-19 pandemic. In particular, we study the characteristics of the IoT solutions hosted on a large online IoT community (i.e., Hackster.io) throughout the year of 2020. The study: (a) explores the proportion, types, and nations of IoT solutions/engineers that contributed to defeating COVID-19, (b) characterizes the complexity of COVID-19 IoT solutions, and (c) identifies how IoT solutions are perceived by the surrounding community. Our results indicate that IoT engineers have been actively working towards providing solutions to help their societies, especially in the most affected nations. Our findings (i) provide insights into the aspects IoT practitioners need to pay more attention to when developing IoT solutions for COVID-19 and to (ii) outlines the common IoT solutions and technologies available to humans to deal with the current challenges.
Project description:ABSTRACT Infantile hemangiomas are the most common tumors seen in pediatrics. Recent clinical research has led to marked advances in understanding, including the recognition that a wide spectrum of clinical severity exists and that these tumors are significantly more complex than originally thought. This article addresses some of the most common clinical questions and scenarios surrounding infantile hemangiomas, based on the most recent research to date.
Project description:Many human malignancies are associated with aberrant regulation of protein or lipid kinases due to mutations, chromosomal rearrangements and/or gene amplification. Protein and lipid kinases represent an important target class for treating human disorders. This review focus on 'the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery. Although the '10 things' have been, to a certain extent, chosen arbitrarily, they cover in a comprehensive way the past and present efforts in kinase drug discovery and summarize the status quo of the current kinase inhibitors as well as knowledge about kinase structure and binding modes. Besides describing the potentials of protein kinase inhibitors as drugs, this review also focus on their limitations, particularly on how to circumvent emerging resistance against kinase inhibitors in oncological indications.
Project description:BackgroundAt the start of the COVID-19 pandemic, guidance was needed more than ever to direct frontline healthcare and national containment strategies. Rigorous guidance based on robust research was compromised by the emergence of the pandemic and the urgency of need for guidance. Rather than aiming to "get guidance right", guidance developers needed to "get guidance right now".AimTo examine how guidance developers have responded to the need for credible guidance at the start of the COVID-19 pandemic.MethodsAn exploratory mixed-methods study was conducted among guidance developers. A web-based survey and follow-up interviews were used to examine the most pertinent challenges in developing COVID-19 guidance, strategies used to address these, and perspectives on the implications of the COVID-19 pandemic on future guidance development.ResultsThe survey was completed by 46 guidance developers. Survey findings showed that conventional methods of guidance development were largely unsuited for COVID-19 guidance, with 80% (n = 37) of respondents resorting to other methods. From the survey and five follow-up interviews, two themes were identified to bolster the credibility of guidance in a setting of extreme uncertainty: (1) strengthening end-user involvement and (2) conjoining evidence review and recommendation formulation. 70% (n = 32) of survey respondents foresaw possible changes in future guidance production, most notably shortening development time, by reconsidering how to balance between rigour and speed for different types of questions.Conclusion"Getting guidance right" and "getting guidance right now" are not opposites, rather uncertainties are always part of guidance development and require guidance developers to balance scientific robustness with usability, acceptability, adequacy and contingency. This crisis points to the need to acknowledge uncertainties of scientific evidence more explicitly and points to mechanisms to live with such uncertainty, thus extending guidance development methods and processes more widely.