Identification of Immune complement function as a determinant of adverse SARS-CoV-2 infection outcome.

ABSTRACT: Understanding the pathophysiology of SARS-CoV-2 infection is critical for therapeutics and public health intervention strategies. Viral-host interactions can guide discovery of regulators of disease outcomes, and protein structure function analysis points to several immune pathways, including complement and coagulation, as targets of the coronavirus proteome. To determine if conditions associated with dysregulation of the complement or coagulation systems impact adverse clinical outcomes, we performed a retrospective observational study of 11,116 patients who presented with suspected SARS-CoV-2 infection. We found that history of macular degeneration (a proxy for complement activation disorders) and history of coagulation disorders (thrombocytopenia, thrombosis, and hemorrhage) are risk fa

SUBMITTER: Ramlall V 

PROVIDER: S-EPMC7273262 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature