The association between circulating levels of vitamin D and inflammatory markers in the first 2 years after colorectal cancer diagnosis.

ABSTRACT:

Background

Calcitriol, the active form of vitamin D, may inhibit colorectal cancer (CRC) progression, which has been mechanistically linked to an attenuation of a pro-inflammatory state. The present study investigated the associations between circulating 25 hydroxy vitamin D₃ (25(OH)D₃) levels and inflammatory markers (IL10, IL8, IL6, TNFα and hsCRP) in the 2 years following CRC diagnosis.

Methods

Circulating 25(OH)D₃ levels and inflammatory markers were assessed at diagnosis, after 6, 12 and 24 months from 798 patients with sporadic CRC participating in two prospective cohort studies. Associations between 25(OH)D₃ levels and individual inflammatory markers as well as a summary inflammatory z-score were assessed at each time

SUBMITTER: Wesselink E 

PROVIDER: S-EPMC7273344 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature