Polymorphic Inversions Underlie the Shared Genetic Susceptibility of Obesity-Related Diseases.

ABSTRACT: The burden of several common diseases including obesity, diabetes, hypertension, asthma, and depression is increasing in most world populations. However, the mechanisms underlying the numerous epidemiological and genetic correlations among these disorders remain largely unknown. We investigated whether common polymorphic inversions underlie the shared genetic influence of these disorders. We performed an inversion association analysis including 21 inversions and 25 obesity-related traits on a total of 408,898 Europeans and validated the results in 67,299 independent individuals. Seven inversions were associated with multiple diseases while inversions at 8p23.1, 16p11.2, and 11q13.2 were strongly associated with the co-occurrence of obesity with other common diseases. Transcriptome analysis

SUBMITTER: Gonzalez JR 

PROVIDER: S-EPMC7273535 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature