Characterization of Myxovirus resistance protein in birds showing different susceptibilities to highly pathogenic influenza virus.

ABSTRACT: We compared the Mx expression and anti-viral function and the 3D structure of Mx protein in four species: chicken (Gallus gallus), whooper swan (Cygnus cygnus), jungle crow (Corvus macrorhynchos), and rock dove (Columba livia). We observed different mortalities associated with highly pathogenic avian influenza virus (HPAIV) infection to understand the relationship between Mx function as an immune response factor and HPAIV proliferation in bird cells. Different levels of Mx were observed among the different bird species after virus infection. Strong Mx expression was confirmed in the rock dove and whooper swan 6 hr after viral infection. The lowest virus copy numbers were observed in rock dove. The virus infectivity was significantly reduced in the BALB/3T3 cells expressing rock dove and ju

SUBMITTER: Hagiwara K 

PROVIDER: S-EPMC7273593 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature