Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells.

ABSTRACT:

Background

Understanding the signalling pathways involved in angiogenesis, and developing anti-angiogenic drugs are one of the major focuses on cancer research. Herein, we assessed the effect of CPTH6, a lysine acetyltransferase inhibitor and anti-tumoral compound, on angiogenesis-related properties of both endothelial and cancer cells.

Methods

The in vitro effect of CPTH6 on protein acetylation and anti-angiogenic properties on endothelial and lung cancer cells was evaluated via wound healing, trans-well invasion and migration, tube formation, immunoblotting and immunofluorescence. Matrigel plug assay, zebrafish embryo and mouse xenograft models were used to evaluate in vivo anti-angiogenic effect of CPTH6.

Results

CPTH6 impaired in vitro endothelial angiogenesis-rel

SUBMITTER: Di Martile M 

PROVIDER: S-EPMC7273677 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature