Optimal use of biologics with endoscopic balloon dilatation for repeated intestinal strictures in Crohn's disease.

ABSTRACT:

Background and aim

Intestinal strictures in Crohn's disease (CD) have a high rate of repeated surgery. As alternatives to surgery, endoscopic balloon dilatation (EBD), immunomodulators (IMs), and antitumor necrosis factor alpha (anti-TNFα) have been proposed. We aimed to assess the effectiveness of the combined therapy with anti-TNFα and EBD in preventing intestinal stricture recurrence and surgery in patients with CD.

Methods

This retrospective cohort study included patients from the nationwide administrative database in Japan who were hospitalized and underwent at least one EBD between 1 April 2010 and 31 March 2017. The effectiveness of anti-TNFα was evaluated by performing survival analysis for the primary outcome. We selected the inverse probability of treatment weighti

SUBMITTER: Uda A 

PROVIDER: S-EPMC7273704 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature