A Multiscale Model for the Self-Assembly of Coat Proteins in Bacteriophage MS2.

ABSTRACT: The self-assembly of viral capsids is an essential step to the formation of infectious viruses. Elucidating the kinetic mechanisms of how a capsid or virus-like particle assembles could advance our knowledge about the viral lifecycle, as well as the general principles in self-assembly of biomaterials. However, current understanding of capsid assembly remains incomplete for many viruses due to the fact that the transient intermediates along the assembling pathways are experimentally difficult to be detected. In this paper, we constructed a new multiscale computational framework to simulate the self-assembly of virus-like particles. We applied our method to the coat proteins of bacteriophage MS2 as a specific model system. This virus-like particle of bacteriophage MS2 has a unique feature th

SUBMITTER: Wang B 

PROVIDER: S-EPMC7273741 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature