Identification of Altered miRNAs in Cerumen of Dogs Affected by Otitis Externa.

ABSTRACT: Otitis externa is one of the most common diseases in dogs. It is associated with bacteria and yeast, which are regarded as secondary causes. Cerumen is a biological substance playing an important role in the protection of ear skin. The involvement of cerumen in immune defense is poorly understood. MicroRNAs can modulate the host immune response and can provide promising biomarkers for several inflammatory and infectious disorder diagnosis. The aims of this study were to profile the cerumen miRNA signature associated with otitis externa in dogs, integrate miRNAs to their target genes related to immune functions, and investigate their potential use as biomarkers. Cerumen was collected from healthy and otitis affected dogs and the expression of miRNAs was profiled by Next Generation Sequencin

SUBMITTER: Lecchi C 

PROVIDER: S-EPMC7273745 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature