Intravenous Ibuprofen Reduces Opioid Consumption During the Initial 48 Hours After Injury in Orthopedic Trauma Patients.

ABSTRACT:

Objectives

To evaluate the efficacy of intravenous (IV) ibuprofen (Caldolor) administration in the management of acute pain in orthopedic trauma patients and to minimize opioid use.

Design

Randomized controlled trial, double-blind, parallel, placebo-controlled.

Setting

Level 1 Trauma Center.

Patients

A total of 99 consecutive orthopedic trauma patients with fractures of the ribs, face, extremities, and/or pelvis were randomized to receive either 800 mg IV ibuprofen (53 patients) or placebo (44 patients) administered every 6 hours for a total of 8 doses within 48 hours of admission and the same PRN medications along with 20-mg IV/PO Pepcid twice a day. To establish pain reduction efficacy, the analysis was consequently performed in the modified intent-to-treat g

SUBMITTER: Weisz RD 

PROVIDER: S-EPMC7274153 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature