Evolution of buffering in a genetic circuit controlling plant stem cell proliferation.

ABSTRACT: Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs^1,2. The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit^1,2. In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation³. Here, we show that compensation^4,5 operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impac

SUBMITTER: Rodriguez-Leal D 

PROVIDER: S-EPMC7274162 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature