Low Serum Bicarbonate and CKD Progression in Children.

ABSTRACT:

Background and objectives

Studies of adults have demonstrated an association between metabolic acidosis, as measured by low serum bicarbonate levels, and CKD progression. We evaluated this relationship in children using data from the Chronic Kidney Disease in Children study.

Design, setting, participants, & measurements

The relationship between serum bicarbonate and a composite end point, defined as 50% decline in eGFR or KRT, was described using parametric and semiparametric survival methods. Analyses were stratified by underlying nonglomerular and glomerular diagnoses, and adjusted for demographic characteristics, eGFR, proteinuria, anemia, phosphate, hypertension, and alkali therapy.

Results

Six hundred and three participants with nonglomerular disease contributed

SUBMITTER: Brown DD 

PROVIDER: S-EPMC7274283 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature