Environment-Wide Association Study of CKD.

ABSTRACT:

Background and objectives

Exposure to environmental chemicals has been recognized as one of the possible contributors to CKD. We aimed to identify environmental chemicals that are associated with CKD.

Design, setting, participants, & measurements

We analyzed the data obtained from a total of 46,748 adults who participated in the National Health and Nutrition Examination Survey (1999-2016). Associations of chemicals measured in urine or blood (n=262) with albuminuria (urine albumin-to-creatinine ratio ≥30 mg/g), reduced eGFR (<60 ml/min per 1.73 m²), and a composite of albuminuria or reduced eGFR were tested and validated using the environment-wide association study approach.

Results

Among 262 environmental chemicals, seven (3%) chemicals showed signi

SUBMITTER: Lee J 

PROVIDER: S-EPMC7274289 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature