Management of Active Surveillance-Eligible Prostate Cancer during Pretransplantation Workup of Patients with Kidney Failure: A Simulation Study.

ABSTRACT:

Background and objectives

The general rule that every active malignancy is an absolute contraindication for kidney transplantation is challenged by kidney failure patients diagnosed with active surveillance-eligible prostate cancer during pretransplantation workup. Interdisciplinary treatment teams therefore often face the challenge of balancing the benefits of early kidney transplantation and the risk of metastatic progression. Hence, we compared the quality-adjusted life expectancy of different management strategies in kidney failure patients diagnosed with active surveillance-eligible prostate cancer during pretransplantation workup.

Design, setting, participants, & measurements

A discrete event simulation model was developed on the basis of a systematic literature search

SUBMITTER: Bieri U 

PROVIDER: S-EPMC7274295 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature