Mitochondrial Nutrient Utilization Underlying the Association Between Metabolites and Insulin Resistance in Adolescents.

ABSTRACT:

Context

A person's intrinsic metabolism, reflected in the metabolome, may describe the relationship between nutrient intake and metabolic health.

Objectives

Untargeted metabolomics was used to identify metabolites associated with metabolic health. Path analysis classified how habitual dietary intake influences body mass index z-score (BMIz) and insulin resistance (IR) through changes in the metabolome.

Design

Data on anthropometry, fasting metabolites, C-peptide, and dietary intake were collected from 108 girls and 98 boys aged 8 to 14 years. Sex-stratified linear regression identified metabolites associated with BMIz and homeostatic model assessment of IR using C-peptide (HOMA-CP), accounting for puberty, age, and muscle and fat area. Path analysis identified cluster

SUBMITTER: LaBarre JL 

PROVIDER: S-EPMC7274492 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature