Microbial bile acid metabolites modulate gut RORγ⁺ regulatory T cell homeostasis.

ABSTRACT: The metabolic pathways encoded by the human gut microbiome constantly interact with host gene products through numerous bioactive molecules¹. Primary bile acids (BAs) are synthesized within hepatocytes and released into the duodenum to facilitate absorption of lipids or fat-soluble vitamins². Some BAs (approximately 5%) escape into the colon, where gut commensal bacteria convert them into various intestinal BAs² that are important hormones that regulate host cholesterol metabolism and energy balance via several nuclear receptors and/or G-protein-coupled receptors^3,4. These receptors have pivotal roles in shaping host innate immune responses^1,5. However, the effect of this host-microorganism biliary network on the adaptive immune system

SUBMITTER: Song X 

PROVIDER: S-EPMC7274525 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature