High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila.

ABSTRACT: The function of the central nervous system to regulate food intake can be disrupted by sustained metabolic challenges such as high-fat diet (HFD), which may contribute to various metabolic disorders. Previously, we showed that a group of octopaminergic (OA) neurons mediated starvation-induced hyperactivity, an important aspect of food-seeking behavior (Yu et al., 2016). Here we find that HFD specifically enhances this behavior. Mechanistically, HFD increases the excitability of these OA neurons to a hunger hormone named adipokinetic hormone (AKH), via increasing the accumulation of AKH receptor (AKHR) in these neurons. Upon HFD, excess dietary lipids are transported by a lipoprotein LTP to enter these OA⁺AKHR⁺ neurons via the cognate receptor LpR1, which in turn suppr

SUBMITTER: Huang R 

PROVIDER: S-EPMC7274782 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature