Prevalence and correlates of periodic limb movements in OSA and the effect of CPAP therapy.

ABSTRACT: OBJECTIVE:We sought to assess the prevalence, correlates, and consequences of periodic limb movements of sleep (PLMS) in persons with obstructive sleep apnea (OSA) and the effect (worsening or improvement) of continuous positive airway pressure (CPAP) therapy on PLMS in a large prospective multicenter randomized controlled trial. METHODS:We performed retrospective analyses of data from the Apnea Positive Pressure Long-term Efficacy Study, a prospective multicenter randomized controlled trial. A total of 1,105 persons with OSA enrolled in this study underwent a polysomnographic investigation at baseline, another one for CPAP titration, and another study 6 months after randomization to either active CPAP or sham CPAP. RESULTS:Of all participants, 19.7% had PLM index (PLMI) ≥10/hour, 14.8% ha

SUBMITTER: Budhiraja R 

PROVIDER: S-EPMC7274846 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature