A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.

ABSTRACT:

Rationale

The heart undergoes dramatic developmental changes during the prenatal to postnatal transition, including maturation of cardiac myocyte energy metabolic and contractile machinery. Delineation of the mechanisms involved in cardiac postnatal development could provide new insight into the fetal shifts that occur in the diseased heart and unveil strategies for driving maturation of stem cell-derived cardiac myocytes.

Objective

To delineate transcriptional drivers of cardiac maturation.

Methods and results

We hypothesized that ERR (estrogen-related receptor) α and γ, known transcriptional regulators of postnatal mitochondrial biogenesis and function, serve a role in the broader cardiac maturation program. We devised a strategy to knockdown the expression of ERRα

SUBMITTER: Sakamoto T 

PROVIDER: S-EPMC7274895 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature